(3beta,6alpha,12beta)-3,12,20-Trihydroxydammar-24-en-6-yl beta-D-glucopyranoside
Ginsenoside Rh1
CAS: 63223-86-9
Molecular Formula: C36H62O9
(3beta,6alpha,12beta)-3,12,20-Trihydroxydammar-24-en-6-yl beta-D-glucopyranoside - Names and Identifiers
| Name | Ginsenoside Rh1 |
| Synonyms | Ginsenoside Rh1 GINSENOSIDE RH1 sanchinoside rh1 Sanchinoside Rh1 Ginsenoside Rh1 (Prosapogenin A2 6α-(β-D-Glucopyranosyloxy)-dammara-24-ene-3β,12β,20-triol (20S)-6α-(β-D-Glucopyranosyloxy)dammar-24-ene-3β,12β,20-triol 3β,12β,20-Trihydroxy-5α-dammar-24-en-6α-yl β-D-glucopyranoside (20S)-6α-(β-D-Glucopyranosyloxy)-3β,12β,20-trihydroxydammara-24-ene (3beta,6alpha,12beta)-3,12,20-Trihydroxydammar-24-en-6-yl beta-D-glucopyranoside (3beta,6alpha,12beta)-3,12,20-trihydroxydammar-24-en-6-yl?beta-d-glucopyranoside (3beta,6alpha,9xi,12beta,13xi)-3,12,20-trihydroxydammar-24-en-6-yl beta-D-glucopyranoside |
| CAS | 63223-86-9 |
| InChI | InChI=1/C36H62O9/c1-19(2)10-9-13-36(8,43)20-11-15-34(6)26(20)21(38)16-24-33(5)14-12-25(39)32(3,4)30(33)22(17-35(24,34)7)44-31-29(42)28(41)27(40)23(18-37)45-31/h10,20-31,37-43H,9,11-18H2,1-8H3/t20-,21+,22-,23+,24+,25-,26-,27+,28-,29+,30-,31+,33+,34+,35+,36-/m0/s1 |
(3beta,6alpha,12beta)-3,12,20-Trihydroxydammar-24-en-6-yl beta-D-glucopyranoside - Physico-chemical Properties
| Molecular Formula | C36H62O9 |
| Molar Mass | 638.88 |
| Density | 1.23 |
| Boling Point | 755.1±60.0 °C(Predicted) |
| Specific Rotation(α) | (c, 0.88 in MeOH)+20 |
| Flash Point | 410.457°C |
| Solubility | Soluble in water, methanol, ethanol, insoluble in petroleum ether, ether, benzene. |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | White crystalline powder |
| pKa | 12.91±0.70(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.581 |
| MDL | MFCD09951797 |
| Physical and Chemical Properties | White powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from ginseng. |
| In vitro study | The effect of Ginsenoside Rh1 is examined on adipogenesis in 3T3-L1 cells. Ginsenoside Rh1 potently inhibits the adipogenesis, as assessed by Oil-red O staining and lipid contents in 3T3-L1 adipocytes. Ginsenoside Rh1, at concentrations of 50 μM and 100 μM, inhibit the adipogenesis by 50% and 63%, respectively.The expression levels of adipocytespecific genes such as PPAR-γ, C/EBP-α, FAS, aFABP and some genes are examined during early phase of differentiation such as Pref-1, C/EBP-δ and Glucocorticoid receptor (GR). After the treatment with Ginsenoside Rh1 in 3T3-L1 cells, mRNA is extracted on 18 h and 24 h for Pref-1, C/EBP-δ and GR and day 8 for PPAR-γ, C/EBP-α, FAS, aFABP. Then, the expression profiles of adipocyte-specific genes are investigated by RT-PCR. PPAR-γ, C/EBP-α, FAS, and aFABP expressions are significantly increased in DMI-stimulated differentiated adipocyte compared to those of non-stimulated adipocyte cells. However, treatment with DMI in the presence of Ginsenoside Rh1 significantly suppresses the expression levels of PPAR-γ, C/EBP-α, FAS, and aFABP in a dose- dependent manner, whereas the expression levels of Pref-1, C/EBP-δ and GR are not affected. |
| In vivo study | When high-fat diet (HFD) fed mice for 8 weeks, body and epididymal fat weight gains are significantly increased compared to those of low-fat diet (LFD)-fed mice. However, when Ginsenoside Rh1 is treated in HFD-fed mice, body and epididymal fat weight gains are significantly decrease compared with those of the HFD-fed mice. TG, glucose, insulin, total cholesterol, and HDL levels in the blood are significantly increased in HFD-fed mice group compared to LFD-fed mice group. Treatment with Ginsenoside Rh1 in HFD-fed mice significantly lowers TG level alone. |
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Mobile: 86+15671228036
QQ: 2853786052
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Product Name: Ginsenoside Rh1 Visit Supplier Webpage Request for quotationCAS: 63223-86-9
Tel: 18301782025
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Mobile: 18021002903
QQ: 3008007409
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